Journal: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology

Article Title: High throughput toxicity screening and intracellular detection of nanomaterials

doi: 10.1002/wnan.1413

Figure Lengend Snippet: Advantages and Limitations of High Throughput Screening Methods to Study Toxicity of Nanomaterials

Article Snippet: A microfluidic chip‐based IFC developed by Amphasys AG (Switzerland) can analyze single cells without any specific sample preparation prior to measurement., , Compared to other impedance‐based cytometers, e.g., Z series Coulter Counters or the CASY from Roche, the microfluidic chip‐based IFC can cover impedance measurements at a broader frequency range, and thus yield information regarding the size and number of cells and, in addition, their membrane capacitance and cytoplasmic conductivity., IFC gives a snapshot of the cellular state of single cells based on the changed resistance within the chip‐channel caused by the passing cells.

Techniques: High Throughput Screening Assay, Flow Cytometry, Multiplexing, Fluorescence, Imaging, Biomarker Discovery, Spectroscopy, Cell Culture, Battery, Single Particle, Concentration Assay, Clinical Proteomics, Membrane, Single Photon Emission Computed Tomography, Marker, In Vitro, In Vivo, High Content Screening, Multiplex Assay, Suspension, End Point Assay, Gene Expression, Amplification, Microarray, Single Cell Gel Electrophoresis, Staining